Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic Acid | CAS 76-05-1
Trifluoroacetic Acid | Purity: >=99.0% | M. W.: 114.02 | 76-05-1 | 200-929-3
Covachem LCMS Grade TFA (Trifluoroacetic acid) 25ml
CovaChem's LCMS Grade Trifluoroacetic acid (TFA) is well suited as a chromatography additive for difficult to separate analytes in HPLC and LCMS applications. CovaChem's LCMS TFA is an ideal additive for separations of peptides in peptide synthesis applications. Trifluoroacetic acid is widely used to separate both protected amino acid chains and deprotected peptides. Due to the amino and carboxylate groups having vastly different pka values, synthetic peptides can be particularly challenging to separate, The HPLC separation of peptides is much more easily achieved with 0.1% Trifluoroacetic acid being present in the mobile phase.
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 | C25H31F3N12O10S2 | 5 MG
Ceftolozane TFA is the trifluoroacetic acid (TFA) salt of a cephalosporin antibiotic supplied as a solid for research use. It is used to study and inhibit Gram-negative bacterial infections and as a synthetic building block for development of new antibiotic derivatives.
- Cephalosporin-class antibiotic active against Gram-negative bacteria.
- Useful as a synthetic intermediate for antibiotic development.
- High purity (98.2%) suitable for analytical and synthetic work.
- White to off-white solid form for easy handling and storage.
- Available in milligram-scale quantities for research applications.
- Store at -20°C sealed; in solvent, store at -80°C up to 6 months or -20°C up to 1 month.
- For research use only; not for human or veterinary use.
Medchemexpress LLC Ceftolozane TFA 1mg | 1628046-32-1 | 1MG
Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer[1
TARGETMOL CHEMICALS INC LEVOROTATION NIMORAZOLE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Levorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.
eMolecules Trifluoroacetic acid, peptide synthesis grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100ml | 537677722
Trifluoroacetic acid, peptide synthesis grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100ml | 537677722
Apexbio Technology LLC 2X hyperfusion plus master mix (With dye) 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb 2X Hyperfusion plus master mix (With dye) is a ready-to-use 2 premix solution containing polymerase dNTPs an already optimized buffer system and dye Our mix is ideal for any detection and the PCR product can be directly electrophoresed after the amplification without the need to add a loading buffer
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 5mL
Trifluoroacetic acid | Purity: 99% | MW:114.02 | 76-05-1 | MFCD00004169 | 5mL
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid HPLC | 76-05-1 | MFCD00004169 |
Trifluoroacetic acid HPLC | Purity: >=99.9% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 |
Medchemexpress LLC PSMA I&S TFA | 98.15% | 1413.43 | 5 MG
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, intended for research use only.
- Precursor of 99mTc-labeled PSMA-targeting ligand
- For research use only
Medchemexpress LLC PSMA I&S TFA | 98.2% | 1413.43 | 1 MG
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, appearing as a white to off-white solid.
- Target PSMA
- Inhibits immunology/inflammation pathway
- Soluble in DMSO (100 mg/mL)
- Soluble in various in vivo dissolution methods
- Store at -20°C, protected from light and under nitrogen